Assad, bolstered by military victory in the desert city of Palmyra, was quoted by Russia's RIA news agency as saying a new draft constitution could be ready in weeks and a government that included opposition, independents and loyalists could be agreed.
While the distribution of portfolios and other technical issues would need to be discussed at Geneva peace talks, which resume next month, "these are not difficult questions", Assad said.
Opposition negotiators immediately dismissed Assad's remarks, saying that a political settlement could be reached only by establishing a transitional body with full powers, not another government under Assad.
"What Bashar al-Assad is talking about has no relation to the political process," said George Sabra of the High Negotiations Committee.
Syria's crisis erupted five years ago with protests against Assad which were put down with force.
It descended into a civil war which has killed more than 250,000, drawn in global military powers and helped Islamic State establish its self-declared caliphate.
Nearly five million refugees have been driven abroad.
